Reinventing Genome Engineering
Reinventing Genome Engineering

High efficiency genome editing

Booster modules to improve efficiency of nuclease-based genome editing methods with high efficiency of gene editing via homologous recombination. Algentech’s proprietary donor DNA amplification system active in the vicinity of the target is combined with the expression of proteins engineered to facilitate homologous recombination for high efficiency of repair, sequence swap, insertion or mutation.

Development of nuclease-free systems through engineering of multidomain proteins able to bind to the donor and recognize the target for optimal delivery at the right site.

Green bioproduction platform for sustainable production of complex molecules

High yield: Algentech’s proprietary mini-chromosome amplification technology enables  high expression of complex molecules in plant chloroplasts. Units are not integrated in the chloroplast genome, enabling high expression of large polycistronic units independently.

Sustainable production: plants consume CO2 as carbon source to produce molecules of interest, waste is minimal as by-products such as cellulose and starch can be recycled and reused.

Multiple applications: plants are transformed into green factories combining high biomass with superior product yield to produce  valuable compounds for multiple industrial applications such as active pharmaceuticals, cosmetic ingredients, pigments, biosurfactant and novel biomaterials.

Mitochondria transformation

Algentech’s unique transport system  shuttling nucleic acids into the mitochondria via specific DNA or RNA recognition domains and mitochondria addressing modules opens new paths for research and industrial applications

Production of male sterile plants expressing CMS-inducing ORFs in mitochondria for the production of novel hybrid varieties. This unique molecular tool can also be used for discovery and functional analysis of novel CMS-inducing sequences.

Alternative expression system: mitochondrial expression systems can be adapted for specific industrial applications.